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Molecular Immunotoxicology

Description for Molecular Immunotoxicology

The first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models. Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.

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Antibody Expression and Production (Cell Engineering) Online Book

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Antibody Expression and Production (Cell Engineering)

Description for Antibody Expression and Production (Cell Engineering)

Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.

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Programmed Cell Death in Cancer Progression and Therapy: 615 (Advances in Experimental Medicine and Biology) Download for free

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Programmed Cell Death in Cancer Progression and Therapy: 615 (Advances in Experimental Medicine and Biology)

Description for Programmed Cell Death in Cancer Progression and Therapy: 615 (Advances in Experimental Medicine and Biology)

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically. With this book, we give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, this book will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeut

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Disease-Proof: The Remarkable Truth About What Makes Us Well Free Online

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Disease-Proof: The Remarkable Truth About What Makes Us Well

Description for Disease-Proof: The Remarkable Truth About What Makes Us Well

“If you want to build better health and a better future, this book makes an excellent tool kit.”—David A. Kessler, MD, author of The End of Overeating and former commissioner of the FDA

It sometimes seems as if everyone around us is being diagnosed with a chronic illness—and that we might soon join them. In Disease-Proof, leading specialist in preventive medicine Dr. David Katz draws upon the latest scientific evidence and decades of clinical experience to explain how we can slash our risk of every major chronic disease—heart disease, cancer, stroke, diabetes, dementia, and obesity—by an astounding 80%. Dr. Katz arms us with skillpower: a proven, user-friendly set of tools that helps us make simple behavioral changes that have a tremendous effect on our health and well-being. Inspiring, groundbreaking, and prescriptive, Disease-Proof proves making lasting lifestyle changes is easier than we think.

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 3 - Role in Specific Diseases Online

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 3 - Role in Specific Diseases

Description for Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 3 - Role in Specific Diseases

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration.  From these well-developed foundations, researchers, translati

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Retinal Degenerative Diseases: Mechanisms and Experimental Therapy (Advances in Experimental Medicine and Biology) Download Book

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Retinal Degenerative Diseases: Mechanisms and Experimental Therapy (Advances in Experimental Medicine and Biology)

Description for Retinal Degenerative Diseases: Mechanisms and Experimental Therapy (Advances in Experimental Medicine and Biology)

This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012).  A majority of those who will speak and present posters at the meeting will contribute to this volume.  The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70.  The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them.  Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candid

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Immunobiology of the Shark Online Book

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Immunobiology of the Shark

Description for Immunobiology of the Shark

Sharks belong to the oldest vertebrate species that possess immune systems similar to that of mammals. This makes them a great model species to study the fundamentals of the mammalian immune system. This book describes the cellular, genetic, and molecular specifics of immune systems in sharks and uses them to understand shark immunity as well as the evolution of immune systems in more recently-evolved vertebrates. Written by global experts, the book will be a resource for immunologists, geneticists, ecologists, evolutionary and conservation biologists, and investigators engaged in shark research.

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Freedom Summer Online Book

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Freedom Summer

Description for Freedom Summer

In June 1964, over one thousand volunteers--most of them white, northern college students--arrived in Mississippi to register black voters and staff "freedom schools" as part of the Freedom Summer campaign organized by the Student Non-Violent Coordinating Committee. Within ten days, three of them were murdered; by the summer's end, another had died and hundreds more had endured bombings, beatings, and arrests. Less dramatically, but no less significantly, the volunteers encountered a "liberating" exposure to new lifestyles, new political ideologies, and a radically new perspective on America and on themselves.

Films such as Mississippi Burning have attempted to document this episode in the civil rights era, but Doug McAdam offers the first book to gauge the impact of Freedom Summer on the project volunteers and the period we now call "the turbulent sixties." Tracking down hundreds of the original project applicants, and combining hard data with a wealth of personal recollection

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Medical Microbiology: with STUDENT CONSULT Online Access, 6e (Medical Microbiology (Murray)) Download for free

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Medical Microbiology: with STUDENT CONSULT Online Access, 6e (Medical Microbiology (Murray))

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Description for Medical Microbiology: with STUDENT CONSULT Online Access, 6e (Medical Microbiology (Murray))

The new edition of this popular text presents microbiology in a succinct, easy-to-use, and engaging manner. Clear discussions explain how microbes cause disease in humans, and review the updated vaccines and new antibiotics currently available to treat these diseases. Expert coverage of basic principles, the immune response, laboratory diagnosis, bacteriology, virology, mycology, and parasitology ensures that you'll understand all the facts vital to the practice of medicine today. A revised artwork program illustrates the appearance of disease, simplifying complex information, while text boxes and additional summary tables emphasize essential concepts and learning issues for more efficient exam review. Online access to Student Consult-where you'll find the complete contents of the book, fully searchable...Integration Links to bonus content in other Student Consult titles...updated features for both students and instructors...and much more-further enhances your study and exponentially b

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Epstein-Barr Virus: Latency and Transformation Free Download

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Epstein-Barr Virus: Latency and Transformation

Description for Epstein-Barr Virus: Latency and Transformation

Epstein-Barr virus (EBV) is a human gamma herpes virus that is best known for being the causative agent of infectious mononucleosis in man. A fascinating feature of this virus is its ability to persist in the host, and it is estimated that more than 95% of adults are carriers of the virus. Importantly, EBV can transform latently infected primary cells from healthy individuals into cancerous ones, thereby causing important human cancers such as B-cell neoplasms (e.g. Burkitt's lymphoma and Post-transplant lymphomas), certain forms of T-cell lymphoma, and some epithelial tumors (e.g. gastric carcinomas). Understanding viral latency, what triggers viral reactivation and the mechanism of transformation of normal host cells into malignant cells are critical for the development of strategies for the prevention and control of this intriguing virus and related cancers. In this book, expert EBV virologists comprehensively review this important subject from a genetic, biochemical, immunological,

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Immunology for Pharmacy Free Online

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Immunology for Pharmacy

Description for Immunology for Pharmacy

With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations.Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students.165 full-color illustrations help to illuminate difficult concepts.Factors That Influence the Immune Response chapter covers biological agents includi

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Integrative Rheumatology (Weil Integrative Medicine Library) Free Online

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Integrative Rheumatology (Weil Integrative Medicine Library)

Description for Integrative Rheumatology (Weil Integrative Medicine Library)

Integrative Rheumatology offers a new and much-needed perspective in disease and symptom management, blending conventional medicine with alternative approaches not typically included in a Western medical practice. While conventional treatments can provide considerable symptomatic relief and can even slow the progression of many rheumatologic conditions, integrative treatment incorporating lifestyle interventions, mind-body approaches, and practices such as acupuncture and meditation into conventional medical therapies can improve quality of life, reduce medication dosages, and are generally better tolerated. In this book, researchers and clinicians highlight specific gaps in conventional rheumatologic care and examine how alternative approaches may be ideally suited to address these missed opportunities. Here, the authors introduce topics not typically addressed in conventional rheumatology texts, including nutritional therapies, exercise, herbal medicine, mind/body approaches, Ayurved

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Statistical Modelling of Molecular Descriptors in QSAR/QSPR in review

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Statistical Modelling of Molecular Descriptors in QSAR/QSPR

Description for Statistical Modelling of Molecular Descriptors in QSAR/QSPR

This handbook and ready reference presents a combination of statistical, information-theoretic, and data analysis methods to meet the challenge of designing empirical models involving molecular descriptors within bioinformatics. The topics range from investigating information processing in chemical and biological networks to studying statistical and information-theoretic techniques for analyzing chemical structures to employing data analysis and machine learning techniques for QSAR/QSPR.
The high-profile international author and editor team ensures excellent coverage of the topic, making this a must-have for everyone working in chemoinformatics and structure-oriented drug design.

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