Antibody Expression and Production (Cell Engineering) Online Book

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Antibody Expression and Production (Cell Engineering)

Description for Antibody Expression and Production (Cell Engineering)

Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.

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Programmed Cell Death in Cancer Progression and Therapy: 615 (Advances in Experimental Medicine and Biology) Download for free

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Programmed Cell Death in Cancer Progression and Therapy: 615 (Advances in Experimental Medicine and Biology)

Description for Programmed Cell Death in Cancer Progression and Therapy: 615 (Advances in Experimental Medicine and Biology)

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically. With this book, we give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, this book will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeut

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Disease-Proof: The Remarkable Truth About What Makes Us Well Free Online

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Disease-Proof: The Remarkable Truth About What Makes Us Well

Description for Disease-Proof: The Remarkable Truth About What Makes Us Well

“If you want to build better health and a better future, this book makes an excellent tool kit.”—David A. Kessler, MD, author of The End of Overeating and former commissioner of the FDA

It sometimes seems as if everyone around us is being diagnosed with a chronic illness—and that we might soon join them. In Disease-Proof, leading specialist in preventive medicine Dr. David Katz draws upon the latest scientific evidence and decades of clinical experience to explain how we can slash our risk of every major chronic disease—heart disease, cancer, stroke, diabetes, dementia, and obesity—by an astounding 80%. Dr. Katz arms us with skillpower: a proven, user-friendly set of tools that helps us make simple behavioral changes that have a tremendous effect on our health and well-being. Inspiring, groundbreaking, and prescriptive, Disease-Proof proves making lasting lifestyle changes is easier than we think.

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 3 - Role in Specific Diseases Online

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 3 - Role in Specific Diseases

Description for Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 3 - Role in Specific Diseases

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration.  From these well-developed foundations, researchers, translati

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Retinal Degenerative Diseases: Mechanisms and Experimental Therapy (Advances in Experimental Medicine and Biology) Download Book

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Retinal Degenerative Diseases: Mechanisms and Experimental Therapy (Advances in Experimental Medicine and Biology)

Description for Retinal Degenerative Diseases: Mechanisms and Experimental Therapy (Advances in Experimental Medicine and Biology)

This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012).  A majority of those who will speak and present posters at the meeting will contribute to this volume.  The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70.  The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them.  Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candid

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Immunobiology of the Shark Online Book

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Immunobiology of the Shark

Description for Immunobiology of the Shark

Sharks belong to the oldest vertebrate species that possess immune systems similar to that of mammals. This makes them a great model species to study the fundamentals of the mammalian immune system. This book describes the cellular, genetic, and molecular specifics of immune systems in sharks and uses them to understand shark immunity as well as the evolution of immune systems in more recently-evolved vertebrates. Written by global experts, the book will be a resource for immunologists, geneticists, ecologists, evolutionary and conservation biologists, and investigators engaged in shark research.

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Freedom Summer Online Book

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Freedom Summer

Description for Freedom Summer

In June 1964, over one thousand volunteers--most of them white, northern college students--arrived in Mississippi to register black voters and staff "freedom schools" as part of the Freedom Summer campaign organized by the Student Non-Violent Coordinating Committee. Within ten days, three of them were murdered; by the summer's end, another had died and hundreds more had endured bombings, beatings, and arrests. Less dramatically, but no less significantly, the volunteers encountered a "liberating" exposure to new lifestyles, new political ideologies, and a radically new perspective on America and on themselves.

Films such as Mississippi Burning have attempted to document this episode in the civil rights era, but Doug McAdam offers the first book to gauge the impact of Freedom Summer on the project volunteers and the period we now call "the turbulent sixties." Tracking down hundreds of the original project applicants, and combining hard data with a wealth of personal recollection

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